Neuropsychological and brain functional changes across the different phases of Schizoaffective Disorder

Resumen ......................................................................................................................... 17 Introduction ..................................................................................................................................... 21 Nosology ....................................................................................................................................... 21 Epidemiology ................................................................................................................................ 23 Psychopathological symptoms ..................................................................................................... 24 Diagnosis ...................................................................................................................................... 25 Clinical studies of schizoaffective disorders ................................................................................. 31 Treatment ..................................................................................................................................... 35 Neurobiological findings ............................................................................................................... 35 Genetics .................................................................................................................................... 36 Neurocognition ......................................................................................................................... 37 Neuroimaging .......................................................................................................................... 38 Hypotheses and objectives of the thesis ........................................................................................ 46 Objectives ..................................................................................................................................... 46 Hypotheses ................................................................................................................................... 47 Methods ........................................................................................................................................... 48 Participants ................................................................................................................................... 48 Design of the study ....................................................................................................................... 49 Recruitment .................................................................................................................................. 50 Psychopathological assessment ................................................................................................... 53 Cognitive assessment ................................................................................................................... 54 Neuroimaging procedure ............................................................................................................. 56 Statistical analysis ......................................................................................................................... 59 Results .............................................................................................................................................. 61 Study 1: “Brain functional abnormality in schizoaffective disorder: an fMRI study” .................. 62